有机不饱和体系的硼化官能化

有机含硼化合物在生物医药和有机合成中具有广泛的用途。芳烃、烯烃以及炔烃等有机不饱和体系的硼化官能化研究能够实现结构复杂、功能多样的有机含硼化合物的高效合成。本项目拟通过设计合成一系列廉价金属络合物催化剂；发展一系列芳烃、烯烃、炔烃的硼化官能化或硼氢化反应，精确控制反应的区域选择性和立体化学选择性；通过物理有机化学的实验手段和理论计算等研究方法阐明硼化官能化的反应机理与选择性控制因素。本项目拟开展的催化剂设计合成以及新反应方法学发现符合绿色有机合成的概念，将为有机含硼化合物合成拓展新方法，为芳烃、烯烃以及炔烃的转化利用提供新途径。

Boron-containing organic compounds are widely used in the field of biomedicine and organic synthesis. The development of borylation-functionalization reactions for organic unsaturated systems such as arenes, alkenes and alkynes could realize the efficient synthesis of boron-containing organic compounds with complex structures and various functions. In this project, a series of low-cost metal complex catalyst will be designed and synthesized for the development of borylation-functionalization reactions with arenes, alkenes, and alkynes. In these reactions, the regionselectivity as well as stereoselectivity will be controlled precisely. By means of physical organic chemistry experimental methods and theoretical calculations, the reaction mechanism and the control factors of reaction selectivity will be elucidated. The design and synthesis of new catalytic systems and development of new reactions in this project will meet the concept of green chemistry. Moreover, this project will expand new methods for the synthesis of boron-containing organic compounds as well as provide new route for the transformation and utilization of arenes, alkenes and alkynes.