Disulfide catalysis and protein folding in bacterial virulence

支持二硫键形成的分子机制对我们理解蛋白质折叠和功能产生了重大影响。该项目将对细菌病原体中二硫化物催化途径的基本领域做出重大贡献，从而有助于保持澳大利亚在这一领域研究的强大国际形象。这项工作将导致对研究科学家和学生进行包括分子遗传学、蛋白质生物化学和结构生物学在内的技术培训。我们的研究结果可能会影响未来疫苗研究的方向，这些疫苗研究的病原体会导致危及人类生命的感染，从而改善健康状况，减少医疗保健支出。

The molecular mechanisms that underpin disulfide bond formation have had a major impact on our understanding of protein folding and function. This project will make a major contribution to fundamental areas of disulfide catalysis pathways in bacterial pathogens and thus help maintain a strong international profile for Australian research in this field. The work will lead to training of research scientists and students in techniques that include molecular genetics, protein biochemistry and structural biology. Our findings may impact future directions for vaccine research on pathogens that cause life threatening infections in humans and therefore lead to improved health and reduced health care expenditure.