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Regulation of heterochromatin by the Retinoblastoma protein in cell cycle control and cancer

Regulation of heterochromatin by the Retinoblastoma protein in cell cycle control and cancer
视网膜母细胞瘤蛋白在细胞周期控制和癌症中对异染色质的调节
批准号:
223267
负责人:
Dick Frederick A
金额:
$52.56万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-03-01 至 2016-03-01

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中文摘要
翻译
细胞增殖失控是癌症的基本特征之一。除了不想要的细胞生长,癌细胞的基因构成往往是不稳定的。这使他们获得了新的特征,从而促进了攻击性的增强
英文摘要
Deregulated cell proliferation is one of the fundamental characteristics of cancer. In addition to unwanted cell growth, the genetic make-up of cancer cells is often unstable. This allows them to acquire new characteristics that promote increased aggres
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Chromosome organization by RB and Condensin II in metastasis.
Epigenetic regulation of repeat expression by RB and EZH2 in cancer
Roles of retrotransposon silencing in genome instability and cancer therapy
Integration of proliferative control mechanisms by the RB protein
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