Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions

蛋白质之间的相互作用调节了所有基本的细胞过程，然而蛋白质组合的结构复杂性意味着它们往往很难用传统的分析方法来表征。该项目将开发和展示新的质谱学方法，以分子水平描述生物蛋白质复合体的结构和相互作用，这反过来可能为治疗一系列人类健康疾病的药物的合理设计奠定基础。该项目还将为年轻的研究人员提供最高国际标准的质谱学和蛋白质科学方面的培训，以利于澳大利亚的工业和研究。

Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.