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Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs

Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs
金属基抗糖尿病药物的设计与机理研究
批准号:
DP1095310
负责人:
Prof Peter Lay
金额:
$31.35万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-14 至 2013-12-04

项目摘要

项目成果

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中文摘要
翻译
金属补充剂,如铬和钒,因其据称的减脂和抗糖尿病活性而被广泛使用。然而,关于这些金属离子的有效性和安全性,以及它们是否在预防糖尿病方面发挥重要作用,或者在某些情况下,它们是否是癌症的危险因素,还有很多需要了解。这项研究将为了解这些金属配合物如何发挥其抗糖尿病作用,以及如何使它们更安全、更有效地治疗在发达国家迅速蔓延的2型糖尿病提供一个基本的认识。
英文摘要
Metal supplements, such as chromium and vanadium, are consumed widely for their purported fat reduction and anti-diabetic activities. However, much is still to be learnt about the efficacy and safety of such metal ions and whether they have an essential role in the prevention of diabetes or, in some instances, are a risk factor for cancer. The research will provide a fundamental understanding of how these metal complexes exert their anti-diabetic effects and how they can be made safer and/or more efficacious for the treatment of type 2 diabetes, which is a rapidly expanding epidemic in developed countries.
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Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
  • 批准号:
    DP210101632
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $42.2万
  • 财政年份:
    2021
  • 负责人:
    Prof Peter Lay
  • 依托单位:
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies
  • 批准号:
    LE200100043
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $25.94万
  • 财政年份:
    2020
  • 负责人:
    Prof Peter Lay
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Bioinorganic chemistry between immune cell and pathogen
  • 批准号:
    DP180102741
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $37.48万
  • 财政年份:
    2018
  • 负责人:
    Prof Peter Lay
  • 依托单位:
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs
  • 批准号:
    DP160104172
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $34.92万
  • 财政年份:
    2016
  • 负责人:
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  • 依托单位:
海外基金