The development of copper-free click chemistry to label biomolecules within living cells

了解细胞如何工作是现代生物医学科学进步的核心，然而，由于缺乏适当的工具，许多细胞过程对研究人员来说是不可见的。这项提议将应用现代化学方法来设计新的化学工具，以可视化活细胞内的生物分子，并研究细胞功能。该项目汇集了化学、干细胞和疟疾方面的专家，并应用于开发急需的新疗法。这项研究将推进生物医学研究，为澳大利亚科学创造竞争优势，为国家带来潜在的经济回报。

Understanding how cells work is central to modern advances in biomedical science, however many cellular processes are invisible to the researcher because of a lack of appropriate tools. This proposal will apply modern chemistry approaches to the design of new chemical tools for visualising biomolecules within living cells and for investigating cell function. This project brings together experts in chemistry, stem cells and malaria and has applications for development of much needed new therapeutics. This research will advance biomedical research and generate new discoveries for a competitive advantage for Australian science, with potential economic return for the nation.