Recombinant Fermentation Kinetics and Modeling: Studies on the Effects of Plasmid Instability & Other Kinetic Parameters on the Productivity of Recombinants

本研究是重组发酵过程的基础生化工程研究。它试图定量研究重组群体动力学，开发一种估计关键参数的方法，并制定重组反应器设计的基本原则。研究的最终目标是最大限度地提高基因产品的生产率，并优化利用相对不稳定的基因工程重组微生物的发酵过程。

This research is a fundamental biochemical engineering study on recombinant fermentation processes. It seeks to quantitatively study recombinant population kinetics, develop a methodology for the estimation of key parameters, and develop basic principles for recombinant reactor design. The ultimate objectives of the research are to maximize the productivity of gene products and to optimize the fermentation processes which utilize relatively unstable genetically engineered recombinant microorganisms.