Mechanistic Studies of Free Radicals and Molecular Aggregates

有机和高分子化学项目的资助 支持内德·波特博士的研究，旨在解释 涉及自由基的化学反应机制， 反应中间体 这种反应在有机化学中很常见。 化学和生命过程的化学，如脂质 氧化、组织损伤和老化。 该补助金涵盖的三个研究领域是：（a）免费 自由基氢过氧化物重排;（B）检查 疏水效应作为化学反应性潜在扰动 和立体化学;和（c）自由基参与的因素的研究 自由基大环化和跨环环化。 反应 脂肪和油与分子氧的自由基反应 会产生氢过氧化物，与老化过程有关。 波特博士的研究涉及化学物质的基础研究 有机分子与分子反应的过程 氧气 自由基也被广泛用于有机 波特小组发现了一种新的方法， 利用自由基构建大环分子。 这项工作 将探讨这种新反应的局限性和可能性。 最后，水对化学反应性的影响， 具有混合溶液的有机分子的立体化学， 肥皂将被调查。 早期证据表明， 肥皂状分子在水中形成的聚集体可以产生巨大的 和不寻常的立体化学效应。

This grant in the Organic and Macromolecular Chemistry Program supports research by Dr. Ned Porter aimed at explaining features of the mechanisms of chemical reactions which involve free radicals as reaction intermediates. Such reactions are quite common in organic chemistry and in the chemistry of life processes, such as lipid oxidation, tissue damage, and aging. The three areas of research covered in this grant are: (a) free radical hydroperoxide rearrangements; (b) examination of the hydrophobic effect as a potential perturbation of chemical reactivity and stereochemistry; and (c) the study of factors involved in free radical macrocyclization and transannular cyclization. The reaction of fats and oils with molecular oxygen, a free radical reaction that generates hydroperoxides, has been implicated in the aging process. Dr. Porter's research involves fundamental studies of the chemical processes involved in the reaction of organic molecules with molecular oxygen. Free radicals are also being used extensively in organic synthesis and the Porter group has discovered a new method for construction of large-ring molecules using free radicals. This work will explore the limitations and possibilities of this new reaction. Finally, the effect of water on the chemical reactivity and stereochemistry of organic molecules that have mixed solutions such as soaps will be investigated. Early evidence indicates that molecular aggregates formed from soap-like molecules in water can exert dramatic and unusual stereochemical effects on these molecules.