Amine Directed, Cobalt Catalyzed Cyclizations in Organic Synthesis (Chemistry)

有机和大分子化学项目的这项资助旨在开发新的合成有机方法，这将允许制备具有生物学和理论意义的新材料。将开发新的合成方法，用于使用钴催化环化的碳碳键的区域特异性形成。区域特异性是通过在两个环化底物中的一个上使用定向配体来获得的。配体定向烯烃-乙炔环化形成环戊烯酮的特异性已经被证明。烯烃-乙炔环化反应（Khand-Pauson反应）所产生的官能团可用于三碳环展开序列。展望了环扩展在天然产物合成问题中的潜在应用。

This grant in the Organic and Macromolecular Chemistry Program is directed towards the development of new synthetic organic methods, which will permit the preparation of new materials of biological and theoretical interest. New synthetic methodology will be developed for the regiospecific formation of carbon-carbon bonds using a cobalt-catalyzed cyclization. Regiospecificity is to be obtained by the use of a directing ligand on one of the two cyclization substrates. Specificity of the ligand directed-olefin-acetylene cyclization to form cyclopentenones has already been demonstrated. The functionality generated in an olefin- acetylene cyclization (Khand-Pauson reaction) can be utilized in a three-carbon ring expansion sequence. Potential applications of the ring expansion to problems in natural product synthesis are envisioned.