Data-led bioengineering to uncover hidden chemical wealth in bacteria

土壤细菌诺卡氏菌是一种尚未开发的被称为天然产物的工业上有价值的化合物的来源。该项目旨在开发创新的生物勘探基因组学技术，建立在微生物学、生物化学和计算统计学的学科基础上，以在诺卡氏菌中发现数百种新的天然产品。该项目将释放具有高经济价值的有效新酶和分子的多样性，可能包括用于保护作物的杀虫剂、用于抗击疾病的生物活性物质，或用于食品和生物燃料生产的新酶。这项研究释放了土壤细菌中隐藏的巨大化学潜力，通过创新的、高价值的工业化学品开发来建立可持续的国民经济增长。

The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high economic value that could include insecticides to protect crops, bioactives to fight diseases, or new enzymes for food and biofuel production. This research unlocks enormous hidden chemical potential in soil bacteria, to build sustainable national economic growth through innovative, high-value industrial chemical development.