Gramicidin/Lipid Co-Crystals

华莱士博士正在确定短杆菌肽A的结构 跨膜离子通道，使用X射线晶体学和共- 短杆菌肽和磷脂的晶体。 目前，水晶 可用于研究，分辨率优于2.0 A。 对这些晶体的光谱研究表明， 分子在共晶内是高度有序的。 质膜负责细胞间的相互作用 与周围环境和邻近细胞的关系。 膜蛋白 在转运过程、细胞间接触和 信号接收 高分辨率资料， 包埋在脂质双层中的蛋白质的结构可以 阐明它们作为通道和受体的功能作用， 提供深入了解蛋白质在疏水介质中的折叠 脂质双层的环境。*//

Dr. Wallace is determining the structure of the gramicidin A transmembrane ion channel using X-ray crystallography and co- crystals of gramicidin and phospholipids. The crystals currently available for study diffract to better than 2.0 A resolution. Spectroscopic studies on these crystals have shown that the lipid molecules are highly ordered within the co-crystals. The plasma membrane is responsible for the interactions of a cell with its environment and neighboring cells. Membrane proteins play a major role in transport processes, cell-cell contact and signal reception. High resolution information concerning the structure of proteins which are embedded in lipid bilayers may elucidate their functional roles as channels and receptors and provide insight into the folding of proteins in the hydrophobic environment of a lipid bilayer.***//