Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
Validation of the human farnesyl pyrophosphate synthase (hFPPS) as a therapeutic target and design of pre-clinical candidates for the treatment of multiple myeloma and neurodegenerative diseases.
验证人法呢基焦磷酸合酶 (hFPPS) 作为治疗靶点，并设计用于治疗多发性骨髓瘤和神经退行性疾病的临床前候选药物。
批准号：
265657
负责人：
Tsantrizos Youla S
金额：
$51.28万
依托单位：
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-09-01 至 2017-09-01
中文摘要
翻译
法呢基焦磷酸合酶（hFPPS）负责法呢基焦磷酸（FPP）的生物合成，法呢基焦磷酸是人体生物化学和生理学中的关键代谢物。 hFPPS的异常高活性与许多疾病的发生有关。
英文摘要
The enzyme farnesyl pyrophosphate synthase (hFPPS) is responsible for the biosynthesis of farnesyl pyrophosphate (FPP), a key metabolite in the biochemistry and physiology of the human body. Abnormally high activity of hFPPS has been implicated in numero
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular Tools that Block Maturation of the Nuclear Lamin A, Leading to Decrease in Proliferation and Metastasis of Pancreatic Ductal Adenocarcinoma and Colorectal Cancer
-
批准号：461368
-
项目类别：Operating Grants
-
资助金额：$78.02万
-
财政年份：2022
-
负责人：Tsantrizos Youla S
-
依托单位：
Validation of the human geranylgeranyl pyrophosphate synthase (hGGPPS) as a therapeutic target for cancer chemotherapy and design of pre-clinical candidates for the treatment of multiple myeloma
-
批准号：380326
-
项目类别：Operating Grants
-
资助金额：$64.34万
-
财政年份：2018
-
负责人：Tsantrizos Youla S
-
依托单位：
Benchmark proprietary pyridine- and thienopyrimidine-based bisphosphonates against the standard of care drug Zometa® in the treatment of multiple myeloma
-
批准号：293953
-
项目类别：Operating Grants
-
资助金额：$11.66万
-
财政年份：2013
-
负责人：Tsantrizos Youla S
-
依托单位：
海外基金
