Enantioselective Organic Syntheses

有了这个奖项，合成有机项目将支持科罗拉多大学化学系Gary A. Molander博士的研究。莫兰德博士的研究主要集中在立体选择合成领域。方法涉及邻近基团的参与，使用光学活性有机金属和利用手性环氧化物形成的基础上提出的研究。莫兰德博士将集中精力研究立体选择性有机合成的三个领域。首先，Molander博士将努力开发一种通用的方法来实现1,4-和1,5-相对不对称诱导，将碳亲核试剂添加到前手性亲电中心。在第二个领域，他将利用内部络合的有机镁的热力学平衡生成手性有机金属。在第三篇文章中，他将探索对映体富集的氧烷在有机合成中的独特用途。提出了几种区域控制和立体控制开环反应的方法，这些方法都是生成对映体富集的有机分子的有效途径。

With this award, the Synthetic Organic Program will support the research of Dr. Gary A. Molander of the Department of Chemistry at the University of Colorado. Dr. Molander's research focuses on the area of stereoselective synthesis. Methodology involving neighboring group participation, the use of optically active organometallics and utilization of chiral epoxides form the basis of the proposed studies. Dr. Molander will center his efforts on three areas of stereoselective organic synthesis. First, Dr. Molander will strive to develop a general method for achieving 1,4- and 1,5-relative asymmetric induction in the addition of carbon nucleophiles to prochiral electrophilic centers. In a second area, he will generate chiral organometallics using thermodynamic equilibration of an internally complexed organomagnesium. In a third, he will probe unique uses of enantiomerically enriched oxiranes in organic synthesis. Several methods for regio- and stereocontrolled ring opening reactions of oxiranes are proposed, all of which constitute useful routs to enantiomerically enriched organic molecules.