Chiral NMR Shift Reagents

这项研究得到了化学系分析和表面化学项目的支持，旨在扩大磁共振光谱的使用，以阐明两种重要类型的分子的手性或手性：环糊精(带有空腔的分子，可以选择性地隔离其他特定大小和形状的分子)和3，5-二硝基苯甲酰氨基酸酯(用于分离不同手性分子的氨基酸的衍生物)。稀土离子将与手性物种结合。镧系元素与被探测分子的接近程度改变了它们的磁共振光谱；对这些位移的量化将导致手性分配的方法。%这项研究得到了化学系分析和表面化学计划的支持，旨在扩大镧系核磁共振移位试剂在手性探测中的应用。环糊精和3，5-二硝基苯甲酰氨基酸酯都将以络合或共价键合的稀土元素作为顺磁移位物种进行研究。绝对构型的指定和手性相互作用的研究是本研究的主要目标。

This research, supported by the Analytical and Surface Chemistry Program in the Division of Chemistry, seeks to expand the use of Magnetic Resonance Spectroscopy to elucidate the handedness or chirality of two important types of molecules: cyclodextrins (molecules with cavities that can selectively sequester other molecules of specific size and shape) and 3,5-dinitrobenzoylamino acid esters (derivatives of amino acids useful in separating molecules of different chirality). Lanthanide ions will be bound to chiral species. Proximity of lanthanides to probed molecules shifts their magnetic resonance spectra; quantification of the shifts will lead to the methods for assigning chirality. %%% This research, supported by the Analytical and Surface Chemistry Program in the Division of Chemistry, seeks to expand the use of lanthanide NMR shift reagents for probing chirality. Both cyclodextrins and 3,5-dinitrobenzoylamino aicd esters will be studied with complexed or covalently bound lanthanides as paramagnetic shift species. Assignment of absolute configuration and study of chiral interactions are primary goals of this research.