Template Effects and Self-replicating Systems

来自有机动力学项目的这笔赠款支持小朱利叶斯·雷贝克教授的继续工作。在麻省理工学院。将研究旨在精确定位分子在空间中的位置以控制其与邻近分子的反应性的系统。特别是，将更详细地审查以前报告的自我复制系统。一种可以与腺嘌呤结合但不发生内部酰化的酰亚胺-酯将被用来关闭分子内碱基对成分并促进指数增长。还将使用更亲油和更易溶的Kemp三酸亚胺，以便提高浓度。为了提高两个核酸组分之间的酰胺形成速度，还将研究邻近络合作用。%将研究以产物作为自身形成模板的自我复制反应。这样的系统处于化学和生物的交界处，为选择、竞争和突变提供了模型，这些都是化学进化的基本组成部分。将进行有效复制子的合成和用于合成肽序列的类似核酸的模板的设计。这些新分子有望在今天的生物结构和它们的益生菌同行之间提供联系。

This grant from the Organic Dynamics Program supports the continuing work of Professor Julius Rebek, Jr. at Massachusetts Institute of Technology. Systems designed to precisely fix the positions of molecules in space in order to control their reactivity with neighboring molecules will be studied. In particular, a previously reported self-replicating system will be examined in greater detail. An imide-ester that can bind adenine, but not undergo internal acylation, will be used to shut down the intramolecular base pair components and promote exponential growth. More lipophilic and soluble Kemp triacid imides will also be used so that the concentrations can be increased. Proximity complexation in order to enhance the rate of amide formation between two nucleic acid components will also be examined. %%% Self-replicating reactions in which the product acts as a template for its own formation will be studied. Such systems stand at the interface of chemistry and biology, and provide models for selection, competition and mutation; the essential components of chemical evolution. The synthesis of efficient replicators and the design of nucleic acid-like templates for the synthesis of peptide sequences will be undertaken. These new molecules are expected to offer a link between today's biological structures and their prebiotic counterparts.