Purchase of NMR Instrumentation

这份来自化学研究仪器项目的合同将帮助加州大学洛杉矶分校化学系为500 MHz核磁共振（NMR）光谱仪购买一套新的控制台和探针，以及一套新的场均匀性垫片。这些项目将与现有的11.5特斯拉超导磁体一起使用，该磁体仍处于良好状态。购置这台仪器将加强的研究项目包括：1)利用合成修饰生物聚合物对dna -药物、分子内dna -肽、碳水化合物- dna和rna -蛋白质相互作用进行多维核磁共振分析；3)新型硼烷、碳硼烷和金属硼烷的合成和反应性研究，以及合成有机化学；4)动态、中柱周期和自由基有机金属化学的探索性研究。加州大学洛杉矶分校的化学系在尖端科学设备的开发、使用和维护方面也有出色的记录，在培养研究生和本科生方面也有出色的记录。在使用这种仪器时。这项建议将有助于购买一台现代核磁共振（NMR）光谱仪。该仪器是加州大学洛杉矶分校从事化学研究的教职员工必不可少的工具。该仪器提供了重要的信息，在大多数情况下可用于确定新合成分子的几何和/或分子结构。

This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at the University of California at Los Angeles in the purchase of a new console and probes and a new set of field homogeneity shims for a 500 MHz nuclear magnetic resonance (NMR) spectrometer. These items will be used with the existing 11.5 Tesla superconducting magnet, which is still in excellent condition. The research projects which will be enhanced by the acquisition of this instrument include: 1) Multidimensional NMR spectral analysis of DNA-Drug, intramolecular DNA-Peptide, carbohydrate-DNA and RNA-Protein interactions using synthetically modified biopolymers, 2) Host-Guest chemistry: Preservation of highly strained molecules by their incarceration, 3) Study of the synthesis and reactivity of novel boranes, carboranes and metallacarboranes, and synthetic organic chemistry, 4) Exploratory studies in dynamic, pericycle, and radical organometallic chemistry. %%% The Department of Chemistry at UCLA also has an excellent record in the development, use and maintenance of cutting-edge scientific equipment and a strong, outstanding record in training their students, both graduate and undergraduate, in the use of such instrumentation. This proposal will assist in the purchase of a modern nuclear magnetic resonance (NMR) spectrometer. This instrument is an essential tool for faculty members at the University of California-Los Angeles engaged in chemical research. The instrument provides important information which in most cases can be used to determine the geometric and/or molecular structure of newly synthesized molecules.