Organic Reactions Using Colbalt Alkyne Complexes

本研究的重点是系统地重新研究Pauson-Khand反应的机理，从而更好地理解这一重要过程。其次，Pauson-Khand反应将作为合成天然产物asteriscanolide的关键步骤。第三，Krafft教授将探索非活化烯烃的亲电加成。有了这个更新奖，合成有机项目将支持佛罗里达州立大学化学系的玛丽·e·克拉夫特博士的研究。克拉夫特教授将把她的工作重点放在钴炔配合物的化学上。本文将对Pauson-Khand反应的机理和合成应用进行研究，以开发碳-碳键构建的新策略。

The focus of this research involves a systematic reinvestigation of the mechanism of the Pauson-Khand reaction which will give a better understanding this important process. Second, the Pauson-Khand reaction will be used as a key step in the synthesis of the natural product asteriscanolide and, third, Professor Krafft will probe electrophilic addition to unactivated alkenes. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Marie E. Krafft of the Department of Chemistry at Florida State University. Professor Krafft will focus her work on the chemistry of cobalt-alkyne complexes. Both mechanistic studies and synthetic applications of the the Pauson-Khand reaction will be carried out in order to develop new strategies for the construction of carbon-carbon bonds.