Potentiometric Sensors and Extraction Media for Carboxylates

分析和表面化学计划的这笔赠款支持韦伯教授研究与开发有用的有机阴离子膜传感器和开发这些阴离子的微萃取设备相关的基本问题和问题。阳离子电位型传感器已经成功地应用于各种物种，其结果在生物分析化学和生物技术领域产生了巨大的影响。韦伯教授建议通过合成新的人工受体来为阴离子物种创造新的传感器，以选择性地将阴离子提取到塑化的聚合物介质中。在神经化学、食品工业和生物技术等领域，迫切需要用于检测羧酸盐、谷氨酸和天冬氨酸等离子的新型阴离子传感器。分析和表面化学计划中的这笔赠款将支持开发实用的有机阴离子膜传感器的研究。其目标是创造一套功能类似于已有的阳离子物种的阴离子传感器。这项研究将涉及人工受体的合成和表征，它将选择性地将阴离子提取到聚合物膜中。传感器将被用来检测阴离子，如酸性神经递质、食物中的分解产物和生物反应器中的废物。

This grant in the Analytical and Surface Chemistry Program provides support for Professor Weber's investigations of the fundamental issues and problems associated with the development of useful membrane sensors for organic anions and the development of microextraction devices for these anions. Potentiometric sensors for cations have been successfully implemented for a variety of species, and the results have had a dramatic impact in the fields of bioanalytical chemistry and biotechnology. Professor Weber proposes to create new sensors for anionic species by synthesizing new artificial receptors for the selective extraction of anions into plasticized polymer media. New anion sensors for ions such as carboxylates, glutamate and aspartate are urgently needed in such diverse areas as neurochemistry, the food industry and biotechnology. This grant in the Analytical and Surface Chemistry Program will support research into the development of practical membrane sensors for organic anions. The goal is to create a suite of anion sensors similar in function to those already existing for cationic species. The research will involve the synthesis and characterization of artificial receptors which will selectively extract anions into polymeric membranes. The sensors will be used to detect anions such as acidic neurotransmitters, decomposition products in food, and waste products in bioreactors