Catalysts with D2 Symmetry for Asymmetric Cyclopropanations by Vinylcarbenoids

DAVIES本研究集中在铑（II）催化剂与D2的使用上。 用乙烯基卡宾进行对映选择性环丙烷化的对称性。 这项工作将评估一系列潜在的催化剂，并将应用于 手性环丙烷氨基酸、核苷的合成 衍生物和一类新的倍半萜类，称为山茱萸烷。 的 导致羧酸铑（II）的手性诱导的因素也将 被阐明。有了这个奖项，合成有机计划是 支持Huw M博士的研究。L.戴维斯 维克森林大学的化学系。 戴维斯教授将专注于 研究使用铑（II）催化剂来实现合成 光学活性环丙烷衍生物。

DAVIES This research is centered on the use of rhodium(II) catalysts with D2 symmetry for enantioselective cyclopropanation with vinylcarbenoids. The work will evaluate a range of potential catalysts and will be applied to the synthesis of chiral cyclopropane amino acids, nucleoside derivatives and a new class of sesquiterpenes called tremulanes. The factors leading to chiral induction by rhodium(II) carboxylates will also be elucidated.With this award, the Synthetic Organic Program is supporting the research of Dr. Huw M. L. Davies of the Department of Chemistry at wake Forest University. Professor Davies will focus his work on the use of rhodium(II) catalysts to achieve the the synthesis of optically active cyclopropane derivatives.