CAREER: Applications In Capillary Electrophoresis

这个教师早期职业发展（CAREER）项目，在分析和表面化学计划的支持下，旨在开发毛细管电泳作为表征非共价相互作用，如主客体络合反应的方法。 位于洛杉矶的加州州立大学的Gomez教授和他的本科生和硕士生将开发金属离子亲和色谱支持物、β-环糊精二聚体和毛细管电泳柱表面的小配体，并在其表面制备具有末端配体的毛细管涂层。 非水和混合溶剂毛细管电泳将被检查，以确定这种系统的分析效用。 这个职业生涯项目将向学生介绍一些重要的当代领域，包括表面化学，毛细管电泳，主客体络合反应，蛋白质和肽分离。 另一个教育目标是提高初中和高中少数民族学生对科学职业机会的认识。 在CAREER研究项目的支持下，毛细管电泳正在发展成为一种表征重要的非共价分子间相互作用的方法。 教授戈麦斯是介绍分离科学的本科和硕士水平的研究生，重点是解决实际问题的应用这一新兴领域。 当与毛细管电泳结合使用时，将投入相当大的努力来合成表现出感兴趣的分子间相互作用的分子结构。 新的实验室和课程经验将提供给这些学生在这方面。 将努力让少数民族初中和高中学生参与鼓励他们对科学感兴趣的活动。

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, aims to develop capillary electrophoresis as a method for characterizing noncovalent interactions such as host-guest complexation reactions. Professor Gomez and his undergraduate and master's level students at California State University at Los Angeles will develop metal ion affinity chromatographic supports, immobilize beta-cyclodextrin dimers and small ligands on the surfaces of capillary electrophoresis columns, and prepare capillary coatings with terminal ligands on their surfaces. Nonaqueous and mixed solvent capillary electrophoresis will be examined to determine the analytical utility of such systems. This CAREER project will introduce students to a number of important contemporary areas including surface chemistry, capillary electrophoresis, host- guest complexation reactions, and protein and peptide separations. A further educational aim will be to raise the awareness of minority students at the middle and high school levels regarding career opportunities in science. Capillary electrophoresis is being developed as a method to characterize important noncovalent intermolecular interactions with the support of this CAREER research project. Professor Gomez is introducing this emerging area of separation science to undergraduate and master's level graduate students with emphasis on practical problem solving applications. Considerable effort will be invested in the synthesis of molecular structures that exhibit intermolecular interactions of interest when used in conjunction with capillary electrophoresis. New laboratory and course experience will be provided to these students in this area. Efforts will be made to involve middle and high school minority students in activities that encourage their interest in science.