Purchase of Time-of-Flight Mass Spectrometer

矩阵辅助激光解吸电离飞行时间质谱仪的获得是由分析和表面化学计划和多学科活动办公室支持的。Hercules教授和他在Vanderbilt大学的学生将使用该仪器研究各种聚合物体系的表征、薄层色谱板的快速定性和定量分析、FKBP结合蛋白的定量分析以更好地了解其在钙稳态中的作用以及黄曲霉毒素的检测等问题。这台仪器是这个研究项目的核心，它将取代一台使用了15年的老仪器。正在购买一种能够对复杂的有机和生物材料进行高灵敏度和选择性分析的替代质谱仪。正在研究的材料涵盖了广泛的聚合物，包括重要的生物化合物，如结合蛋白FKBP和剧毒黄曲霉毒素B1。使用该仪器将开发非常广泛的应用和分析方法。该质谱仪的重要组成部分包括基质辅助激光解吸电离样品导入和飞行时间质量分析。

The acquisition of a matrix assisted laser desorption ionization time-of-flight mass spectrometer is supported by the Analytical and Surface Chemistry Program and the Office of Multidisciplinary Activities. Professor Hercules and his students at Vanderbilt University will use this instrument to study problems such as the characterization of diverse polymer systems, the rapid qualitative and quantitative analysis of thin-layer chromatography plates, the quantitative analysis of FKBP binding proteins to better understand its role in calcium homeostasis, and the detection of aflatoxins. This instrument is central to this research program and it will replace a failing fifteen year old instrument. A replacement mass spectrometer is being purchased with the capability of doing highly sensitive and selective analysis of complex organic and biological materials. The materials being studied cover a wide range of polymers and include important biological compounds such as the binding protein FKBP and the highly toxic aflatoxin B1. A very broad range of applications and methods of analysis will be developed using this instrument. Important components of this mass spectrometer include matrix assisted laser desorption ionization sample introduction and time- of-flight mass analysis.