Macromolecular Structure Database

这一奖项授予罗格斯大学，支持开发和运行蛋白质和其他生物大分子的原子坐标在线数据库，这些蛋白质和其他生物大分子的三维结构已通过实验确定。大多数已知的结构是通过使用X射线散射或核磁共振获得的。该数据库将使用现代关系数据库技术来获取、存档和分发有关单个分子的信息，使数据库查询能够调查数据库的全部内容，并促进与其他在线数据库的链接，例如那些提供蛋白质和基因组序列信息的数据库。Pi和她在罗格斯大学、国家标准与技术研究所和加州大学圣地亚哥分校的同事们在数据库建设和操作的各个方面都很熟练，并在用于生成结构数据的实验技术方面拥有专业知识。蛋白质和其他大分子的三维结构知识在应用和基础现代生物学中都非常重要。在这些信息至关重要的研究类型中，包括新发现的基因功能的确定以及新药的设计和修饰。随着这类信息量的增加，可以预期在理解酶和其他细胞成分的功能相互作用方面有新的用途。这项工作的很大一部分将取决于通过中央储存库获得资金的数据的可用性。

9814284This award to Rutgers University supports the development and operation of an online database of atomic coordinates of proteins and other biological macromolecules whose three-dimensional structures have been determined experimentally. Most known structures have been obtained through use of x-ray scattering or nuclear magnetic resonance. The database will use modern relational database technologies to acquire, archive and distribute information about individual molecules, to enable database queries that survey the entire content of the database, and to facilitate linkage to other online databases, such as those providing protein and genomic sequence information. The PI and her colleagues at Rutgers University, the National Institute of Standards and Technology and the University of California at San Diego are skilled in all aspects of database construction and operation, and have expertise in the experimental techniques used to generate structural data.Knowledge of the three-dimensional structure of proteins and other macromolecules is of great importance in both applied and basic modern biology. Among the types of studies for which such information is critical are the determination of the function of newly discovered genes and the design and modification of new pharmaceuticals. As the amount of such information increases, new uses in understanding the functional interaction of enzymes and other cellular constituents can be expected. Much of this work will depend on the availability of data through the central repository being funded.