Sequential Integration of FT-NMR for Science Majors in the Chemistry Curriculum

该项目涉及对我们目前的60 Mhz连续波核磁共振光谱仪进行硬件/软件升级，使其能够作为多核FT仪器使用。我们力求让尽可能多的理科生接触到各种各样的现代化学仪器技术。相对较短的光谱采集时间，加上离线数据简化和分析，将使Wittenberg的所有科学专业学生都能获得使用这种现代光谱技术的经验。此外，在化学课程的广泛课程中，化学专业将利用这种技术作为静态和动态分子结构的普遍探针。课程早期部分的顺序性质允许学生以分层的方式介绍FT-NMR实验的各个方面，其中每个主题都建立在先前的知识和技能之上。实验将包括在一般化学中使用FT-NMR作为磁性和电负性的间接探针，在有机化学中使用1H和13C NMR谱进行结构分析，在分析化学中进行定量分析，在物理化学中进行动力学分析和弛豫时间研究，在生物化学中使用1H和31p谱进行结构分析，在无机化学中使用1H、13C、31p和11B谱进行静态和动态分析。

This project involves the acquisition of a hardware/software upgrade to our current 60 Mhz continuous wave NMR spectrometer that will allow it to function as a multinuclear, FT instrument. We seek to have the largest number of science students possible get hands-on exposure to a wide variety of modern instrumental techniques in chemistry. The relatively short spectrum acquisition time, coupled with off-line data reduction and analysis, will allow all science majors at Wittenberg to get experience using this modern spectroscopic technique. Further, in a wide range of courses in the Chemistry curriculum, chemistry majors will utilize this technique as a ubiquitous probe of static and dynamic molecular structure. The sequential nature of the early part of the curriculum allows the students to be introduced to various aspects of the FT-NMR experiment in a layered fashion, where each topic builds upon prior knowledge and skills. Experiments will include the use of FT-NMR as an indirect probe of magnetism and electronegativity in general chemistry, structure analysis by 1H and 13C NMR spectra in organic chemistry, quantitative analysis in analytical chemistry, kinetics analysis and relaxation time studies in physical chemistry, structure in biochemistry using 1H and 31p spectra, and static and dynamic analysis in inorganic chemistry using 1H, 13C, 31p, and 11B spectra.