Late-Metal Metallacyclobutene Chemistry

在这个由无机、生物无机和有机金属化学项目支持的项目中，加州大学圣地亚哥分校的约瑟夫·奥康纳博士将对金属环丁烯配合物的合成、结构解析以及形成和反应的机理方面进行研究。尽管这些物种在许多金属介导的转化中起着重要作用，但相对而言，很少有很好的表征例子。因此，将为过渡后金属环丁烯配合物设计新的合成路线。这些化合物将用于结构研究、明确的反应性研究、新反应的开发以及被认为涉及金属环丁烯中间体的反应的关键步骤的建模。除了发现这些配合物的新合成方法和应用外，拟议的研究将解决它们的合成和反应的立体控制问题。本项目涉及一类被称为金属环丁烯的有机金属化合物的制备和反应性的研究。这些研究感兴趣的例子包含后期转变因素。主要目标是开发新的合成方法，可用于天然产物及其同源物的全合成。因此，这些新方法将对药物的制备有价值。

In this project, which is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program, Dr. Joseph O'Connor of the University of California - San Diego will pursue an investigation of the synthesis, structural elucidation, and mechanistic aspects of the formation and reactions of metallacyclobutene complexes. Even though these species play important roles in a number of metal-mediated transformations, there are relatively few well characterized examples. Thus, new synthetic routes will be devised for late-transition metallacyclobutene complexes. These compounds will be used for structural studies, well defined reactivity studies, the development of new reactions, and the modeling of key steps in reactions that are thought to involve metallacyclobutene intermediates. In addition to uncovering new synthetic approaches to and applications of these complexes, the proposed studies will address stereocontrol of their synthesis and reactions.This project involves investigations of the preparation and reactivity of a class of organometallic compound known as metallacyclobutenes. The examples of interest for these studies contain late transition elements. The major objective is the development of new synthetic methods that may be used in total synthesis of natural products and their homologs. As such, the new methods will be valuable to the preparation of pharmaceuticals.