Data System Upgrades for Mass Spec/NMR Core Facility

在化学研究仪器和设施(CRIF)计划的支持下，位于双城的明尼苏达大学化学系将为其质谱仪/核磁共振核心设施获得数据系统升级。该设备将加强一些领域的研究，包括a)光合作用中间体的调查；b)植物激素的代谢调节和生长素生物学的基因组方法；c)松皮甲虫的生物化学和化学生态学；d)氮代谢；细胞内脂结合蛋白的结构和功能研究；以及e)维生素K依赖的蛋白质和二氧化硫与一氧化氮的反应。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。升级的数据系统将提高整个设施的效率，增加教育活动，并改善调查人员获得仪器的机会。这些研究的结果将在许多领域产生影响，包括生物化学、分子生物学和生物物理学、化学和植物病理学。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Minnesota in Twin Cities will acquire a data system upgrade for their Mass Spectrometer/NMR core facility. This equipment will enhance research in a number of areas including a) investigations on photosynthetic intermediates; b) metabolic regulation of the plant hormones and genomic approaches to auxin biology; c) biochemistry and chemical ecology of pine bark beetles; d) nitrogen metabolism; structure-function studies of intracellular lipid binding proteins; and e) vitamin K-dependent proteins and sulfur dioxide reactions with nitric oxide. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. Upgraded data systems will increase efficiency of the entire facility, increase educational activities and improve investigator access to instrumentation. The results from these studies will have an impact in a number of areas including biochemistry, molecular biology and biophysics, chemistry, and plant pathology.