New Approaches for Efficiency in Synthetic Organic Chemistry

在有机化学和高分子化学项目的支持下，斯坦福大学化学系的巴里·M·特罗斯特教授正在开发合成复杂有机分子的新的有效方法。他正在探索一些钯、铂和钚催化的转化，包括合成跳跃和共轭双烯、带有不饱和侧链的丁烯内酯和交叉共轭三烯、丙炔醇异构化为烯，以及烯醛异构化为不饱和酯。多组分循环提供了对各种功能的高效访问。将设计和开发催化对映体选择性的pi-烯丙基钯、钼、钚和钨为基础的方法，金属的选择同时决定化学和立体化学结果。基于亲核催化的新型环化策略正在为合成多肽开辟了前所未有的新途径。随着我们对分子结构和反应活性的了解的增加，有机合成的实践正在经历着焦点的变化，现在更多的问题不是是否可以合成复杂的目标，而是如何合成。实际的合成源于一组基本的合成反应的存在，而该基础组的局限性决定了有机合成可以在多大程度上实现经济、高效和环保。在有机化学和高分子化学计划的支持下，斯坦福大学化学系的Barry M.Trost教授正在开发新的选择性反应，这些反应增加了我们合成复杂有机分子的技术，这些技术日益成为从生物学到材料科学的众多应用的基础。

With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and efficient approaches for the synthesis of complex organic molecules. He is exploring a number of palladium, platinum, and ruthenium-catalyzed transformations, including the synthesis of skipped and conjugated dienes, butenolides with unsaturated side chains, and cross-conjugated trienes, the isomerization of propargylic alcohols to enals, and the isomerization of ynals to unsaturated esters. Multicomponent cyclizations afford efficient access to a variety of functionalities. Catalytic enantioselective pi-allyl palladium, molybdenum, ruthenium, and tungsten-based methodologies will be designed and developed, with the choice of metal dictating both the chemical and the stereochemical outcomes. Novel cyclization strategies based on nucleophilic catalysis are opening new doors for unprecedented approaches to polypeptide synthesis.As our knowledge of the structure and reactivity of molecules increases, the practice of organic synthesis is undergoing a change in focus, with the question now more often asked being not if a complex target can be synthesized, but rather how. Practical syntheses derive from the existence of a basic set of synthetic reactions, and the limitations of that base set define the extent to which organic syntheses may be made economical, efficient, and environmentally conscious. With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and selective reactions which add to our arsenal of techniques for the synthesis of the complex organic molecules increasingly forming the basis of a myriad of applications, ranging from biology to materials science.