Biosurface Contact and Bioadhesion Studies Using AFM: A RUI Project

在两年的时间里，这项研究将集中在使用原子力显微镜、使用真菌孢子进行生物表面接触和生物黏附的研究。这项研究的其他方面将涉及单核细胞和肝细胞与参考底物的粘连。UB的表面表征专业知识将补充Towson和Frostburg本科生和教职员工进行的研究。美国陆军生物技术计划和美国FDA机械与材料部的IUCB同事也将参与该计划。除了提供对肝细胞、单核细胞和真菌孢子在不同底物上附着强度的定量、随时间变化的评估外，这项研究还将产生可应用于其他涉及细胞和/或颗粒黏附的应用的技术。这些技术可以应用于牙科和医疗行业，以及油漆和静电印刷行业的环境健康问题。

Over a two year period, the research will focus on Biosurface Contact and Bioadhesion Studies Using Atomic Force Microscopy, using fungal spores. Other aspects of the research will address monocyte and hepatocyte adhesion to reference substrata. Surface characterization expertise at UB will supplement the research performed by Towson and Frostburg undergraduates and faculty. IUCB colleagues at the U.S. Army Biotechnology Program and at the US FDA Division of Mechanics and Materials also will participate in the program.In addition to providing quantitative, time dependent evaluations of hepatocyte, monocyte, and fungal spore attachment strengths to different substrata, this study will produce techniques that can be applied to other applications involving cell and/or particle adhesion. These techniques could be applied to the dental and medical industries, as well as environmental health issues of the paint and xerography industies.