Combinatorial Surface Chemistry: Novel Approach Towards Biomimetic Sensor Development

该奖项授予迈阿密大学的罗杰·勒布朗博士，由分析和表面化学项目提供支持。该研究的重点是基于Langmuir-Blodgett技术的表面开发，该技术对目标生物分子具有很高的特异性，可用于传感器的开发。该研究是多学科的，将包括合成、界面化学和分析化学（传感器开发和表征）等领域。该项目的关键目标是：1)利用组合化学方法在水/空气界面合成脂质/有机单分子膜；2)确定单分子膜对目标生物分子的特异性；3)确定在合成过程中使用目标模板是否能增强单分子膜的特异性；4)将传感器与实际生物系统结合使用。这是生物传感器发展前沿的一项新颖的研究计划。它有一定程度的风险，然而，研究者做出一致的努力来解决潜在的问题。少数民族学生参与的可能性很大。这项研究的影响将在组合合成、生物化学、表面化学和传感器发展领域感受到。在未来，如果传感器应用在生物系统中发展，将有潜在的社会影响。

This award to Dr. Roger Leblanc of the University of Miami is supported by the Analytical and Surface Chemsitry Program. The research focuses on the development of surfaces, based on Langmuir-Blodgett techniques, which have high specificity for target biomolecules, and would be used for sensor development. The research is multi-disciplinary and will include the areas of synthesis, interfacial chemistry and analytical chemistry (sensor development and characterization). The key qoals of the project are 1) synthesis of a lipid/organic monolayer at the water/air interface using combinatorial chemistry, 2) determine the monolayer specificity toward target biomolecules, 3) determine whether the specificity of the monolayer be enhanced by using target templates during the synthesis, and 4) use the sensor with actual biological systems. This is a novel research proposal at the frontier of biosensor development. It has a degree of risk, however, the investigator makes a concerted effort to address the potential problems. The potential for involvement of minority students is high. The impact of this research will be felt in the areas of combinatorial synthesis, biochemistry, surface chemistry and sensor development. In the future, there is potential for societal impact if sensor applications develop in biological systems.