CAREER: Cyclophane Carbenes: Nucleophilicity and Catalytic Applications

将探索咪唑和苯并咪唑卡宾的亲核性。将合成新型的非手性和手性[2.2]咪唑并[2.2]咪唑并苯并考察其亲核反应性。该计划的教育部分将在荣誉有机化学实验室课程中引入一种合作学习的形式。学生将被分成小组，在实验期间参观几个站点(独立实验)。在示范和动手活动方面向小学推广也是教育计划的一部分。有了这个职业奖，有机合成计划正在支持纽约州立大学布法罗分校化学系的Steven T.Diver教授的研究和教育活动。我们将研究一类被称为咪唑卡宾的化合物的基础化学。还将完成将这些卡宾封装到刚性框架中，这可能会赋予这些分子不寻常的性质。该计划的教育部分将继续国际学生联合会访问小学，进行示范，并允许将国际学生联合会的合作学习模块实施到荣誉有机化学实验室课程中。

The nucleophility of imidazole and benzimidazole carbenes will be explored. Novel achiral and chiral [2.2] imidazolophanes will be synthesized and their nucleophilic reactivity investigated. The educational component of the plan will introduce a form of collaborative learning into an honors organic chemistry lab course. Students will be divided into small groups and visit several stations (self-contained experiments) during their lab periods. Outreach to elementary schools in terms of demonstrations and hands-on activities is also part of the educational plan.With this CAREER award, the Organic Synthesis Program is supporting the research and educational activities of Professor Steven T. Diver of the Department of Chemistry at the State University of New York, Buffalo. The fundamental chemistry of a class of compounds known as imidazole carbenes will be studied. Encapsulation of these carbenes into a rigid framework which may confer unusual properties onto these molecules will also be accomplished. The educational portion of the plan will continue the PI's visits to elementary schools to give demonstrations and allow the implementation of the PI's cooperative learning modules into an honors organic chemistry lab course.