MRI: Acquisition of a 400 MHz NMR Spectrometer for Research and Research Training in Chemistry at Connecticut College

康涅狄格学院化学系将获得一台400 MHz核磁共振光谱仪，该奖项来自主要研究仪器（MRI）项目。该设备将使研究人员能够开展以下研究：a)串联分子内环化- claisen重排序列作为通往四环体5-7-6-3环体系的便捷途径；B) ingenol环体系的合成策略；C)新型合成具有生物活性的5,7-融合倍半萜；D)萤火虫荧光素类似物的合成与表征；e)萤火虫荧光素酶c端结构域的溶液结构；f)双15n标记coelenterazine的合成与表征；g)非水溶胶-凝胶体系的13C-NMR表征。核磁共振也将用于本科实验课程。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Connecticut College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) tandem intramolecular cyclization-Claisen rearrangement sequence as a facile route to the tetracyclic 5-7-6-3 ring system of phorbol; b) synthetic strategies toward the ingenol ring system; c) novel syntheses of biologically active 5,7-fused sesquiterpenoids; d) synthesis and characterization of firefly luciferin analogs; e) solution structure of the C-terminal domain of firefly luciferase; f) synthesis and characterization of doubly 15N-labeled coelenterazine; and g) the 13C-NMR characterization of nonaqueous sol-gel systems. The NMR will also be used in the undergraduate laboratory courses. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry.