MRI: Acquisition of a 400 MHz Solid-State NMR Spectrometer

牛津迈阿密大学化学和生物化学系将从重大研究仪器(MRI)计划获得这一奖项，从而获得一台400 MHz固态核磁共振(核磁共振)光谱仪。该设备将使研究人员能够开展以下方面的研究：a)膜结合蛋白磷蛋白的特性；b)CREP-1的结构和作用机制的研究；c)金属酶金属β-内酰胺酶的检测，据信导致细菌产生抗生素耐药性；d)有机修饰聚合物及其在组合化学中的应用；e)树枝状大分子对溶胶-凝胶材料的影响；以及f)开发用于色谱分离的新型填充材料。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对许多领域产生影响，特别是药物化学、生物化学和材料化学。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Miami University in Oxford will acquire a 400 MHz solid-state nuclear magnetic resonance (NMR)spectrometer. This equipment will enable researchers to carry out studies on a) the characterization of the membrane-bound protein phospholamban; b) an investigation of the structure and mechanism of action of CREP-1; c) an examination of the metalloenzyme metallo-beta-lactamase, believed responsible for antibiotic resistance in bacteria; d) organically modified polymers and their use in combinatorial chemistry; e) influence of dendrimers on sol-gel materials; and f) development of novel packing materials for chromatographic separations. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas, in particular, medicinal chemistry, biochemistry and materials chemistry.