Upgrade of a 400 MHz NMR Spectrometer

凭借化学研究仪器和设施（CRIF）计划的这一奖项，弗吉尼亚理工学院和州立大学的化学系将升级400 MHz NMR光谱仪。该设备将使研究人员能够进行以下研究：a）制备具有不寻常结构、反应性或物理性质的有机金属络合物（Deck）; B）研究多磺化膦配体的金属络合物在两相反应条件下作为催化剂（Hanson）; c）分离天然产物（金斯顿）; d）轮烷化学（吉布森）; e）有机合成和合成方法学（Carlier）;和f）制备具有新型三维结构的多肽作为多肽中螺旋-转角-螺旋基序的模拟物（Etzkorn）。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些核磁共振研究的结果将在许多领域产生影响，包括有机，聚合物和有机金属化学。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Virginia Polytechnic Institute and State University will upgrade a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out the following research: a) preparation of organometallic complexes with unusual structure, reactivity or physical properties (Deck); b) studies on metal complexes of polysulfonated phosphine ligands as catalysts in biphasic reaction conditions (Hanson); c) isolation of natural products (Kingston); d) rotaxane chemistry (Gibson); e) organic synthesis and synthetic methodology (Carlier); and f) preparation of polypeptides with novel three-dimensional architecture as mimics for the helix-turn-helix motif in polypeptides (Etzkorn). Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including organic, polymer and organometallic chemistry.