SBIR Phase I: Novel Particulate Fluidization Systems for Pulmonary Drug Delivery Applications

[0215073]这个小型企业创新研究项目提出开发新型流化系统，用于合成用于肺部药物输送的纳米封装胰岛素颗粒。通过在胰岛素颗粒表面包裹一层极薄（10-50 nm）的可生物降解聚合物，如聚乳酸（PLA），可以显著改变胰岛素的缓释特性。与传统方法相比，这种独特的方法有几个优点，包括低聚合物负载和无杂质处理。纳米包封方法是利用激光烧蚀薄膜沉积技术包覆在气相流化的药物颗粒。该一期项目将开发批量流化系统，该系统一次可流化多达1公斤的颗粒。该项目的商业应用是在药物输送领域。

0215073SinghThis Small Business Innovation Research project proposes to develop novel fluidization systems that are needed for synthesis of nano-encapsulated insulin particles for pulmonary drug delivery applications. By coating the insulin particle with very thin (10-50 nm) layer of biodegradable polymers such as polylactic acid (PLA), the sustained release characteristics of insulin can be significantly altered. The unique method has several advantages over conventional methods including low polymer loading, and impurity-free processing. The nano-encapsulation method involves using laser ablation thin film deposition technique to coat drug particles which are fluidized in the gas phase. This Phase I project will develop batch scale fluidization systems which are capable of fluidizing up to 1 kg of particles at a time.The commercial applications of this project are in the area of pharmaceutical drug delivery.