SBIR Phase II: Latent-Reactive Surface Modification Reagents for Biofilm Control

这个小企业创新研究第二阶段项目继续开发新的热活化试剂，用于将杀微生物聚合物粘合到各种不透明管道材料的内表面，该项目在第一阶段的先进材料和制造（AM）主题下启动，表面工程子主题(F)。已经开发出具有运输含水混合物所需的大块物理性质的材料；然而，在牙科、制药、食品加工和海洋运输行业中，湿表面生物膜的发展一直是一个严重的问题。水线的表面改性可以减少生物膜的形成，同时保持油管所需的体积特性。光化学在射频等离子体或紫外光引发的基基表面修饰增强医疗设备的表面特性方面已被证明是商业上成功的。然而，这些能源不能有效地改变不透明管道的内表面，如牙科单位使用的水管和制药厂的管道。该项目旨在开发可通过穿透这些不透明装置的热能激活的潜在反应自由基发生器。这种创新的自由基发生器的预定激活方法将提供一种方法来修饰惰性表面，这些表面不能用外部光或等离子体源激活。微生物定植和生物膜形成仍然是牙科和制药工业、卫生保健和公共住宿以及船舶利用对人类健康和产品质量的主要成本和威胁。成功开发用于含水液体可食用产品的不透明运输和储存容器的腔面杀菌防污涂层技术，构成数千万美元的增量市场规模，不受当前商业涂层技术的限制。

This Small Business Innovation Research Phase II project continues the development of new thermally activable reagents for bonding microbicidal polymers to inner surfaces of a variety of opaque tubing materials, initiated in Phase I under the Advanced Materials and Manufacturing (AM) topic, Surface Engineering subtopic (F). Materials have been developed with bulk physical properties needed for transport of aqueous mixtures; however, the development of biofilm on the wet surfaces is a continuing serious problem in the dental, pharmaceutical, food processing, and marine transport industries. Surface modification of waterlines could decrease the formation of biofilm while retaining the desired bulk properties of the tubing. Photochemistry has been proven commercially successful in enhancing the surface properties of medical devices with radical-based surface modification initiated by RF plasma or ultraviolet light. However, these energy sources are not effective for modifying the inner surfaces of opaque tubes such as waterlines used with dental units and plumbing in pharmaceutical plants. This project is designed to develop latent-reactive radical generators activatible with thermal energy which penetrates these opaque devices. This innovative approach to scheduled activation of radical generators will provide a method to modify inert surfaces which cannot be activated with external light or plasma sources. Microbial colonization and biofilm formation remain a major cost and threat to human health and product quality for dental and pharmaceutical industries, health care and public lodging, and marine vessel utilization. Successful development of microbicidal and antifouling coating technology for the luminal surface of opaque transport and storage vessels for aqueous liquid ingestible products, constitute an incremental market size of tens of millions of dollars, not subject to current commercial coating technology.