RUI: Electrophilic Reactions of Triflic Acid and Chlorosulfonyl Isocyanate with Fluorosubstituted Terminal Alkenes

通过这项本科院校研究（RUI）奖，有机和大分子项目支持洛马拿撒勒学院化学系Dale F. Shellhamer博士的研究。该研究考察了与一个或多个氟原子取代的烯烃加成的缺电子物种的区域化学和立体化学。研究将结合合成化学和机械化学，以回答有关有机含氟化合物的反应性的基本问题。由于含氟有机化合物在现代医学、工业和农业中具有重要意义，因此了解其多种化学行为非常重要。除了增加对机理的理解，这些研究还将产生一类新的分子，这些分子可能在药物化学中被证明是有用的。在有机和大分子化学项目的支持下，Shellhammer教授设计了一些研究项目，这些项目可以由化学专业大二的本科生完成。这些学生将合成大量的含氟有机物，使用现代仪器来表征这些化合物，并在每周的研讨会上发表他们的发现。其主要目标是激发本科生对科学的热情，并为学生进入研究生院深造做好准备。这种创新的本科研究方法将为学生提供挑战和准备，并为有机氟化学做出重大贡献。

With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Program supports the research of Dr. Dale F. Shellhamer of the Department of chemistry at Point Loma Nazarene College. The research examines the regio- and stereochemistry of the addition of electron deficient species to alkenes substituted with one or more fluorine atoms. The investigations will blend synthetic and mechanistic chemistry in order to answer fundamental questions concerning the reactivity of organic fluorine-containing compounds. Since fluorinated organic compounds are important in contemporary medicine, industry and agriculture, knowledge of their diverse chemical behavior is quite important. In addition to adding mechanistic understanding, these studies will generate a new class of molecules that may prove useful in medicinal chemistry.With support from the Organic and Macromolecular Chemistry Program, Professor Shellhammer has designed research projects that can be accomplished by undergraduates after their sophomore year of chemistry. These students will synthesize a large number of fluoro organics, use modern instruments to characterize these compounds, and present their findings at weekly seminars. A major goal is to generate enthusiasm for science among undergraduates and prepare students for advanced study in graduate school. This innovative approach to undergraduate research will serve to challenge and prepare students as well as make significant contributions to organo fluorine chemistry.