Designing New Soluble Polymers to Facilitate Separations and Reactions

本研究的重点是展示如何控制、修饰可溶性大分子的溶解性，并将其用于合成和催化。光谱探针的研究将检查共聚物微观结构对聚合物相选择性溶解度的微妙影响，使用平行合成来最小化聚合物合成中通常遇到的多分散性和其他变量的影响。此外，该项目将展示使用共价、离子或环境刺激来控制可溶性聚合物相选择溶解度的新方法。此外，相选择性可溶性聚合物支撑试剂或催化剂的双相混合物将用于促进高稀释反应。该项目将导致合成具有高溶解度和高容量的新型聚合物，用于合成和催化。有了这个更新奖，有机和大分子化学项目支持德克萨斯农工大学化学系David E. Bergbreiter博士的研究和教育活动。Bergbreiter教授将致力于开发新型聚合物载体催化剂和具有有效相选择性能的新型可溶性聚合物载体的制备方法。在双相条件下控制特定相的聚合物浓度的优势，以及这种效果如何促进已知的催化或合成反应及其后续处理是该项目的统一主题。在培养本科生和研究生方面产生了更广泛的影响，这项工作对绿色化学具有重要意义。

The focus of this research is to show how the solubility properties of soluble macromolecules can be controlled, modified and used to advantage in synthesis and catalysis. Studies with spectroscopic probes will examine the subtle effects of copolymer microstructure on polymer phase selective solubility, using parallel syntheses to minimize effects of polydispersity and other variables normally encountered in polymer synthesis. Further, the project will demonstrate new ways to use covalent, ionic or environmental stimuli to control a soluble polymer's phase selective solubility. Also, biphasic mixtures of phase selectively soluble polymer supported reagents or catalysts will be used to facilitate high dilution reactions. The project will lead to the syntheses of new polymers with high solubility with high capacity that are designed for synthesis and catalysis.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. David E. Bergbreiter in the Department of Chemistry at Texas A&M University. Professor Bergbreiter will focus his work on developing methods for preparation of new polymer supported catalysts and new soluble polymer supports with useful phase selective properties. The advantages of controlling polymer concentrations in specific phases under biphasic conditions and how such effects can facilitate known catalytic or synthetic reactions and their workup is the unifying theme of the project. Broader impacts are strong in the area of training for both undergraduate and graduate students and the work has significant implications for Green Chemistry.