Biophotonics: Optical Coherence Elastography and Biomechanical Modeling of Developing Tissues

[05:1992 . 20]目标是发展光学相干弹性成像，并用它来理解微机械力在生物组织发育中的作用。机械性能将用于机械水凝胶模型，以确定规则的组织和模式的生物组织。测量结果将验证这些模型。该项目将创造一种新的生物力学测量和成像工具，改进或改进生物材料设计，洞察组织的功能特性，对未来工程和功能启发组织的潜在影响。使用类似于超声声弹性成像和超声弹性成像的实验方法，提供了有希望的初步结果。展示了OCT成像在控制样品加载后可以在工程组织中诱导的可视化变化的能力。低频振动能量将被用来缓慢加载组织。

0519920BoppartThe goal is to develop optical coherence elastography and use it to understand the role of micromechanical forces on development of biological tissues. The mechanical properties will be used in mechanical hydrogel models to determine rules governing organization and patterning of biological tissue. Measurements will validate the models. The project will create a new tool for biomechanical measurement and imaging, improved or refined biomaterial design, insights into functional properties of tissues, potential impact on future engineered and functionally-inspired tissue Using an experimental approach similar to what has been used for ultrasound sonoelasticity imaging and ultrasound elastography, promising preliminary results are provided, demonstrating the ability of OCT imaging to visualize changes that can be induced in engineered tissue following controlled loading of the sample. Low frequency vibrational energy will be used to slowly load the tissue.