Development of Advanced Structural Techniques for Gas-Phase Ions

在主要研究仪器（MRI）计划的支持下，德克萨斯州A M大学化学系的大卫罗素将开发一种新型的混合线性离子阱-离子迁移率飞行时间质谱仪（LIT-IM-MS），用于气相离子的结构表征，包括小分子，大分子，簇和纳米颗粒。 LIT-IM-MS仪器将结合联合收割机LIT技术、周期聚焦离子导向迁移率漂移池、高分辨率正交飞行时间质谱仪和多阳极微阵列离子检测，可用于电喷雾电离或基质辅助激光解吸电离形成的离子以及小分子离子源的快速（微秒至毫秒）电离后分离和质量分析。 此外，IM-MS还可以对离子-分子和离子-离子反应的产物、溶剂化产物、弱结合的离子簇和弱相互作用的离子簇进行结构研究。虽然该项目的主要重点是仪器开发，但它将为现代尖端质谱技术和相关研究领域的博士后研究员，研究生和本科生提供新的跨学科培训机会。 这项研究建立在德克萨斯A M大学Ionwerks公司的科学家之间现有的合作基础上。和多伦多的AB/MDS-Sciex的科学家。

With support from the Major Research Instrumentation (MRI) Program, David Russell in the Department of Chemistry at Texas A&M University will develop a novel hybrid linear ion trap-ion mobility time of flight mass spectrometer (LIT-IM-MS) for structural characterization of gas-phase ions, including smallmolecules, macromolecules, clusters and nanoparticles. The LIT-IM-MS instrument will combine LIT technology, a periodic focusing ion-guide mobility drift cell, high-resolution orthogonal-TOFMS and multi-anode, micro-array ion detection, which can be used for rapid (microsec to millisec) post-ionization separation and mass analysis of ions formed by electrospray ionization or matrix-assisted laser desorption ionization, as well as small molecule ion sources. In adition, IM-MS structural studies can be performed on products of ion-molecule and ion-ion reactions, solvated species, ion clusters which are weakly bound, and species which are weakly interacting. Although the primary focus of this project is instrument development, it will provide novel interdisciplinary training opportunities for postdoctoral fellows, graduate and undergraduate students in modern, cutting-edge mass spectrometry techniques and allied research areas. The research builds upon existing collaborations between scientists at Texas A&M University, Ionwerks, Inc. in Houston, and scientists at AB/MDS-Sciex in Toronto.