Structure and Function in Foldamers with Heterogeneous Backbones

通过这个奖项，有机和大分子化学项目支持了威斯康星大学化学系Samuel H. Gellman教授的工作。本研究将涉及具有异质骨架的文件夹的结构和功能的调查。文件夹是具有明确构象的低聚分子。这些研究将增加我们对分子内非共价相互作用促进特定和稳定分子形状的方式的理解。关键目标是确定新的文件夹主干和新的设计原则，这些原则将导致前所未有的新颖文件夹。Foldamer的发展为探索局部和全局构象导向力之间的关系提供了机会，从而为分子形状偏好的起源提供了基本的见解。此外，文件夹的独特性质为设计具有有用催化功能的分子提供了新的机会。对已知折叠体的分析和新折叠体的开发为年轻科学家提供了很好的训练，因为这样的研究需要掌握多种技能，包括有机合成，通过各种方法进行构象分析，以及对折叠体函数的评估和改进。Foldamer研究要求学生以前所未有的方式整合这些技能。这个研究领域的复杂性涉及与其他实验室的合作，这加强了学生的训练。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Samuel H. Gellman, of the Chemistry Department at University of Wisconsin, Madison, WI. This research will involve investigations of structure and function in foldamers with heterogeneous backbones. Foldamers are oligomeric molecules that adopt well-defined conformations. These studies will increase our understanding of the ways in which noncovalent interactions within a molecule promote specific and stable molecular shapes. A key goal is to identify new foldamer backbones, and new design principles that will lead to novel unprecedented foldamers. Foldamer development provides an opportunity to probe relationships between local and global conformation-directing forces, thus offering fundamental insights on the origins of molecular shape preferences. In addition, the distinctive properties of foldamers provide new opportunities for the design of molecules with useful catalytic functions.The analysis of known foldamers and the development of new ones provides excellent training for young scientists, because such research requires mastery of multiple skills, including organic synthesis, conformational analysis via a variety of methods, and assessment and refinement of foldamer function. Foldamer research requires students to integrate these skills in unprecedented ways. The complexity of this research area involves collaboration with other laboratories, which enhances student training.