SGER:Novel Concentric, Hollow Silicon Microneedle Array for Diagnostics and Therapeutics

用于诊断和治疗的新型同心中空硅微针阵列Shekhar Bhansali该项目的目标是探索用于诊断和治疗的可植入微针阵列的开发。所提出的新方法是使用同心中空硅微针，外针提供用于分析的路径，内针充当用于药物递送的药物储存器。 这种设计的独特之处在于在存储针和组织之间的气体掺杂固体掺杂硅屏障，这是一种在体内释放药物的新方法。 这项研究是对目前微针技术作为流体提取和原位分析工具或经皮给药方法的一个飞跃。本研究旨在建立一个综合诊断/治疗系统的可行性。制造方法包括不对称掩蔽、干法（各向同性/各向异性）和湿法蚀刻的组合，以产生同心、倾斜尖端和中空的微针。研究目标的成功实现将对医疗保健产生深远的影响，通过使用技术来降低医疗保健成本。 这种方法的成功开发将减少对所有时间的内部监测患者的需求，提高生活质量并减少护理需求。它将导致集成的实时诊断和治疗设备的发展，同时验证一种新的药物输送概念。 智力优势：拟议的研究将不同研究领域（微细加工，传感，医学和材料科学）的发展整合在一个新的方法中，这将促进不同领域的知识和理解。这项研究将为使用新型微制造技术开发微针的综合诊断和治疗工具提供基础。这是跨领域的重大进步。 更广泛的影响：这项研究将能够降低提供医疗保健的成本，减少对护理人员的依赖（这是一个严重短缺的领域），并通过在疾病症状出现时立即提供药物，在黄金时间内做出第一反应，从而提高治疗的整体成功率。 它还将培养学生在新兴的跨学科领域（电气，材料工程，化学，物理和医学）。本科生和代表性不足的群体（少数民族、妇女）将继续参与研究。从桥博士和斯隆少数民族博士的研究人员。将在此程序中绘制程序。这将使PI能够招募来自不同背景的学生，并使他们了解生物传感，微/纳米制造和芯片实验室开发等新领域的需求。

Novel Concentric, Hollow Silicon Microneedle Array for Diagnostics and TherapeuticsShekhar Bhansali The goal of this project is to explore the development of an implantable micro-needle array for diagnostics and theraputics. The novel approach proposed is to use a concentric hollow silicon microneedle, with the outer needle providing a pathway for analysis and the inner needle acting as a drug reservoir for drug delivery. The unique aspect of this design is a gas doped solid doped silicon barrier between the storage needle and the tissue, a novel approach to releasing drugs in-vivo. This research is a quntum jump over current approaches that microneedle technology either as fluid extraction and in-situ analysis tools or for transdermal drug delivery. This research aims to establish the feasibility of an integrated diagnostics/treatment system. The fabrication approach includes a combination of asymmetric masking, dry (isotropic/anisotropic) and wet etching to create concentric, beveled-tipped, and hollow microneedles. Successful accomplishment of the research objectives will have far reaching implications in health care by using technology to reduce the cost of health-care. Successful development of this approach will reduce the need for monitoring patients inhouse all the time, improving the quality of life and reducing the need for nursing. It will lead to the development of integrated real-time diagnostic and therapeutic device while validating a novel drug delivery concept. Intellectual Merit: Proposed research integrates developments in different research areas (microfabrication, sensing, medicine and materials science) in a novel approach that will advance the knowledge and understanding in diverse fields. The research will provide a basis for integrated diagnostics and therapeutics tools using novel microfabrication techniques in developing microneedles. This is a major advance across fields. Broader Impact: This research will enable reduction in cost of delivering health care, reduce the dependence on nursing staff (an area of critical shortage) and allow first response in the golden hour, by delivering drugs as soon as the symptoms of an illness arise improving overall success of treatment. It will also train students in emerging cross-disciplinary areas (Electrical, Materials Engineering, Chemistry, Physics and Medicine). The research will have continued participation of undergraduate students and underrepresented groups (minority, women). The researchers from the Bridge to the Doctorate and Sloan Minority Ph.D. program will be drawn in this program. This will enable the PI to recruit students from diverse backgrounds and expose them to the needs of the new areas of bio-sensing, micro/nanofabrication, and lab-on-chip development.