SGER: Biophotonics: Nano-based Contrast Agent for Molecular Optical-based Imaging of Prostate Cancer

申请人建议通过用适体使纳米金颗粒功能化来增强前列腺癌的靶向性，该适体将特异性地与前列腺特异性膜抗原(PSMA)结合，PSMA是一种在前列腺癌细胞表面表达的具有良好特性的抗原。该抗原可为前列腺癌的早期活体分子成像提供一个理想的高亲和力靶点。该项目的目标是展示设计、功能化和优化用于体内靶向PSMA的金颗粒的能力，以使用光学成像技术早期发现前列腺癌。

Motamedi0632281The applicant proposes to enhance prostate tumor targeting by functionalizing nanogold particles with aptamers that specifically will bind to prostatic specific membrane antigen (PSMA), a well characterized antigen expressed on the surface of prostate cancer cells. This antigen could provide an ideal targeting site with high affinity for early in vivo molecular imaging of prostate cancer. The goal of the project is to demonstrate the ability to design, functionalize and optimize gold particles for in vivo targeting of PSMA for early detection of prostate cancer using optical imaging techniques.