Physical Chemistry of Macromolecules as Probed by High Resolution Solid State NMR

在这个由化学系实验物理化学项目资助的奖项中，耶鲁大学的Kurt Zilm教授和他的研究生和本科生将继续进行实验，以开发新的核磁共振(核磁共振)方法。这项拟议的工作旨在开发新的核磁共振工具，以监测蛋白质中的化学事件，并使用亚微米尺寸的晶体确定其结构。四个模型蛋白质和几个同位素标记的多肽将成为研究新方法的平台，包括作为测量超长距离的手段的核磁共振弛豫，新型低电场核磁共振谐振器的设计，以及新样品纺丝技术的开发。拟议的研究将扩展用于研究重要大分子系统的生物物理化学工具箱。这项工作将影响从化学传感器的设计、化学催化、生物材料的自组装和蛋白质错误折叠等领域。除了培养生物和化学交界处的仪器制造实验者，Zilm教授还通过耶鲁大学科学和技术研究学者(STAR)计划，积极参与自然科学研究中代表性不足群体的招募。

In this award, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Professor Kurt Zilm of Yale University and his graduate and undergraduate research students will continue experiments to develop novel Nuclear Magnetic Resonance (NMR) methods. The proposed work is aimed at developing new NMR tools to monitor chemical events in proteins and to determine their structures using submicron sized crystals. Four model proteins and several isotope labeled peptides will serve as platforms for the investigation of new methods including NMR relaxation as a means for determining very long distances, the design of novel low electric field NMR resonators, and development of new sample spinning technology. The proposed investigations will expand the biophysical chemistry toolbox for the study of important macromolecular systems. This work should impact areas ranging from the design of chemical sensors, chemical catalysis, self-assembly of biomaterials, and protein misfolding. Along with producing students who will be instrument building experimentalists at the interface of biology and chemistry, Professor Zilm is actively involved in the recruitment of underrepresented groups in natural science research through the Yale University Science and Technology Research Scholars (STARS) program.