CAREER: Development of New Oxidative Metal-Catalyzed C-N Bond Forming Reactions

该项目致力于开发新方法，通过直接引入含氮官能团，将廉价的烃类原料快速转化为更复杂的生物相关化合物。 新的金属催化的碳-碳多重键的氧化胺化反应将是这一工作的重要焦点。 还将进行研究，以了解这些反应的基本步骤的基本有机和有机金属机制。 有了这个奖项，有机和高分子化学计划是支持教授福雷斯特迈克尔的化学系在华盛顿大学的研究。 Michael教授的研究工作围绕着开发用于形成C-N键的有效方法，特别是那些耐受空气，水和复杂官能团，在温和条件下操作，并且具有高度立体选择性的方法。 C-N键形成反应工具箱的成功创建将为生物活性小分子提供更有效的途径。

This project is devoted to the development of new methods for rapidly transforming inexpensive hydrocarbon starting materials into more complex biologically relevant compounds by direct introduction of nitrogen-containing functional groups. New metal-catalyzed oxidative amination reactions of carbon-carbon multiple bonds will be a significant focus of this work. Studies to understand the basic organic and organometallic mechanisms of the fundamental steps of these reactions will also be conducted. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Forrest Michael of the Department of Chemistry at the University of Washington. Professor Michael's research efforts revolve around the development of efficient methods for the formation of C-N bonds, specifically those that are tolerant of air, water, and complex functional groups, operate under mild conditions, and are highly stereoselective. The successful creation of a toolbox of C-N bond-forming reactions will provide more efficient access to biologically active small molecules.