Global genetic regulation of carbon metabolism in filamentous fungi.

真菌在医学、农业和工业上都很重要。它们被广泛用于食品、抗生素和化学品生产，并越来越多地用于生产生物乙醇的廉价底物。然而，许多是植物和人类的严重病原体。了解真菌如何控制它们的新陈代谢对于更有效地利用或控制它们具有根本的重要性。该项目利用了一种真菌，这种真菌很容易在实验室中通过先进的遗传技术进行研究，以确定基因在响应可用营养物质变化时打开和关闭的方式。通过比较DNA序列，结果很容易应用于具有经济重要性的真菌。

Fungi are of great importance in medicine, agriculture and industry. They are used extensively for food, antibiotic and chemical production and, increasingly, for generating cheap substrates for bioethanol. However many are serious pathogens of plants and humans. Understanding how fungi control their metabolism is of fundamental importance for their more effective use or control. This project takes advantage of a fungus that is easily studied in the laboratory by advanced genetic techniques to identify the ways in which genes are turned on and off in response to changes in the nutrients available. By comparing DNA sequences the results are readily applied to fungi of economic importance.