LSC: Bloomington Drosophila Stock Center at Indiana University

摘要这是印第安纳大学布鲁明顿果蝇种群中心(BDSC)的五年续展奖项。生物系的凯瑟琳·马修斯博士是私人助理，私人助理包括凯文·库克博士和托马斯·考夫曼博士。BDSC是一个国际公认的库存中心，收集、维护和分发黑腹果蝇的遗传库存。它支持一个庞大而活跃的研究社区，通过使用在这种流行的模式生物体中开发的复杂遗传工具来研究基本的生物过程。它目前的用户群包括超过2400个研究小组和56个国家的35个教学单位。该中心61%的用户来自美国科学家，98%的用户来自学术研究人员。BDSC提供了全面的品系选择，支持果蝇的全谱研究。该文库包括20,000多种不同的遗传菌株，包含超过95,000种已定义的遗传元素，包括突变、染色体异常和转座子插入，以及用于基因错误表达、定点重组和转基因的工具。BDSC将继续维护一个网站，该网站将提供关于库存、其试验用途、订购和账户信息以及监管问题的信息。有关布鲁明顿种群遗传成分的信息完全整合到FlyBase中，FlyBase是为果蝇工作者提供的主要遗传和基因组学数据库。来自布鲁明顿的果蝇菌株已经成为基因调控、细胞生物学、发育生物学、神经生物学、行为生物学、种群生物学、生态学和进化论等实验的关键组成部分，并将继续在许多生物学领域产生广泛的影响。该中心将通过http://flystocks.bio.indiana.edu上的数据库和网站提供英国国防安全委员会的信息，以确保有效利用这些库存

Abstract This is a five-year renewal award to the Bloomington Drosophila Stock Center (BDSC) at Indiana University. Dr. Kathleen Matthews in the Department of Biology is the PI and CoPIs include Drs. Kevin Cook and Thomas Kaufman. The BDSC is an internationally-recognized stock center that collects, maintains and distributes genetic stocks of the fly Drosophila melanogaster. It supports a large and active research community investigating fundamental biological processes through the use of the sophisticated genetic tools developed in this popular model organism. Its current user base includes more than 2,400 research groups and 35 teaching units in 56 countries. 61% of Center use comes from U.S. scientists and 98% of use comes from academic researchers. BDSC provides a comprehensive selection of strains supporting the full spectrum of Drosophila research. The collection consists of over 20,000 different genetic strains containing over 95,000 defined genetic elements including mutations, chromosomal aberrations and transposon insertions as well as tools for gene misexpression, site-specific recombination and transgenesis. BDSC will continue to maintain a website which will provide information concerning stocks, their experimental uses, ordering and account information, and regulatory issues. Information about genetic components of Bloomington stocks is fully integrated into FlyBase, the primary genetic and genomics database for Drosophila workers. Drosophila strains from Bloomington have been key components in experiments in gene regulation, cell biology, developmental biology, neurobiology, behavioral biology, population biology, ecology and evolution and will continue to have a broad impact in many fields of biological endeavor. The Center will assure that the stocks are used effectively by making BDSC information available through databases and websites found at http://flystocks.bio.indiana.edu