Organic and Organometallic Chemistry

无机、生物无机和有机金属化学项目支持加州大学伯克利分校的Robert G. Bergman博士探索钴结合亚硝基和烯烃的新反应，随后涉及配位烯烃和其他试剂的反应。这些反应特别集中于应变和非应变的不饱和烃，因此反应的基本特征可以最清楚地阐明。研究了二硝基烯烃配合物与一系列亲电试剂的反应，以确定在加合物和亲电试剂之间成功形成新的碳-碳键所需的反应组分（例如碱、路易斯酸添加剂）。加合物形成、加合物解离和碳-碳键形成过程的基础研究包括详细的动力学和同位素标记实验。特别注意理解路易斯酸和促进这些转化的启动子的作用。在研究钴基体系的同时，伯格曼教授和他的团队正在探索涉及其他金属和配体的二硝基配合物是否会与简单的烯基衍生物发生类似的化学反应。计算方法，主要是密度泛函理论，用于预测哪些系统可能经历可逆二硝基烯烃加合物的形成。参与本项目的本科生、研究生和博士后均接受过良好的培训。伯格曼教授最近帮助启动了一项新的课程，强调加州阿拉米达县当地公立学校3-5年级学生的科学素养。

The Inorganic, Bioinorganic, and Organometallic Chemistry Program supports the efforts of Dr. Robert G. Bergman of the University of California Berkeley to explore new reactions of cobalt-bound nitrosyl groups and alkenes, followed by reactions involving coordinated alkenes and other reagents. These reactions focus specifically on strained and unstrained, unsaturated hydrocarbons, so that the basic characteristics of the reactions can be most clearly elucidated. Reactions of the dinitrosyl-alkene complexes with a range of electrophiles are examined to determine the reaction components (e.g., base, Lewis acid additives) that are required to successfully form the new carbon-carbon bonds between the adducts and the electrophiles. Fundamental studies of the mechanisms of adduct formation, adduct dissociation and carbon-carbon bond forming processes include detailed kinetics and isotope labeling experiments. Particular attention is paid to understanding the role of the Lewis acid and promoter that facilitates these transformations. Parallel to the studies of the cobalt-based systems, Professor Bergman and his group are exploring whether dinitrosyl complexes involving other metals and ligands will engage in analogous chemistries with simple alkenyl derivatives. Computational methods, primarily with density functional theory, are used to predict which systems are likely to undergo reversible dinitrosyl-alkene adduct formation. Undergraduate, graduate and postdoctoral students working on this program receive excellent training. Professor Bergman has recently helped to initiate a new curriculum emphasizing science literacy for students in grades 3-5 in the local Alameda County, CA public schools.