Oxidative Methods for C-C and C-N Bond Formation

该项目将继续致力于开发通过易氧化反应形成C-C和C-N键的方法。虽然苯酚衍生物的二聚化是公认的过程，但在通过氧化二聚化形成手性双芳烯的催化不对称方法的发展方面取得的进展很少。研究将进一步阐明所涉及的复杂催化循环的机理。假设驱动筛选配体与过渡金属氧化剂将进行，以确定新的有用的催化剂。所开发的催化剂还将用于发现新的氧化反应。通过这个奖项，有机和大分子化学项目支持宾夕法尼亚大学化学系Marisa Kozlowski教授的研究。科兹洛夫斯基教授的研究工作围绕着形成碳碳键和碳氮键的简易氧化方法的发展。由于氧被用作终端氧化剂，这种化学反应将有助于对环境无害的化学合成方法。该方法的成功发展将对制药、农业和材料科学行业的合成产生影响。

This project will continue work on the development of methods for the formation of C-C and C-N bonds by facile oxidative reactions. While dimerizations of phenol derivatives are well-recognized processes, little progress has been made in the development of catalytic asymmetric methods for the formation of chiral biaryls via oxidative dimerization. Studies to further elucidate the mechanism of the complex catalytic cycles involved will be undertaken. Hypothesis driven screening of ligands with transition metal oxidants will be carried out to identify new useful catalysts. The developed catalysts will also be used to discover new oxidative reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Marisa Kozlowski of the Department of Chemistry at the University of Pennsylvania. Professor Kozlowski's research efforts revolve around the development of facile oxidative methods for the formation of C-C and C-N bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis as oxygen is used as the terminal oxidizing agent. Successful development of the methodology will have an impact on synthesis in the pharmaceutical, agricultural, and materials science industries.