Metallacyclobutene and Vinylcarbene Reaction Chemistry

无机、生物无机和有机金属化学项目支持加州大学圣地亚哥分校约瑟夫·m·奥康纳教授对晚期金属金属环丁烯配合物的研究。这些配合物已被认为是许多重要的金属介导转化的关键中间体，包括炔聚合、炔甲基化反应，以及环丙烯、呋喃、吡酮和苯环化合物的合成。开发新的合成途径来达到这些目标，可以最大限度地提高随后的反应性。可分离的金属环丁烯配合物允许进行：a)结构研究，b)明确定义的反应性研究，c)开发新反应，d)对被认为涉及金属环丁烯中间体的反应的关键步骤进行适当的建模，以及e)金属环丁烯衍生产品在化学科学的许多领域的应用。在有机金属化学领域受过训练的本科生和研究生有能力为工业和学术的努力做出重要贡献，这些努力需要在材料、无机和有机化学等领域进行跨学科研究。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the efforts of Professor Joseph M. O'Connor of the University of California San Diego to investigate late-metal metallacyclobutene complexes. Such complexes have been proposed as key intermediates in a large number of important metal-mediated transformations, including alkyne polymerizations, enyne methathesis reactions, and in the synthesis of cyclopropenes, furans, pyrones, and benzannulated compounds. The development of new synthetic routes to these targets maximizes the potential for subsequent reactivity. Isolable metallacyclobutene complexes allow for: a) structural studies, b) well-defined reactivity studies, c) the development of new reactions, d) appropriate modeling of key steps in reactions which are thought to involve metallacyclobutene intermediates, and e) applications of metallacyclobutene-derived products in many areas of the chemical sciences. Undergraduate and graduate students trained in the area of organometallic chemistry are well-positioned to make important contributions to both industrial and academic endeavors which require interdisciplinary research in areas such as materials, inorganic and organic chemistry.