SGER: Single Nanoparticle Surface Plasmon Resonance Imaging

“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。“教授卡尔S.特拉华州大学的Booksh得到化学系分析和表面化学项目的支持，开发了一种扫描单粒子表面等离子体共振光谱技术，用于纳米级异质材料的无标记成像。 将单个金或银纳米颗粒放置在近场扫描光学显微镜的光纤探针的尖端上。等离子体激元场将通过调整纳米粒子探针的尺寸和形态来成形和聚焦。 被探测表面上的折射率变化将影响固定在探针尖端处的颗粒的表面等离子体共振频率。这将使纳米级异质材料的局部介电常数的高分辨率映射，而不需要染料或报告分子。 这种高分辨率、非侵入性的成像方法目前是不可用的。 所提出的成像技术将是有用的表征表面的材料，如自组装膜，脂质双层，和软聚合物，并将导致创新的纳米科学和技术，表面化学和生物技术。

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Professor Karl S. Booksh of the University of Delaware is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to develop a scanning, single particle surface plasmon resonance spectroscopy technique to be applied for label-free imaging of nanoscale heterogeneous materials. A single gold or silver nanoparticle will be placed on the tip of an optical fiber probe of a near-field scanning optical microscope. The plasmon field will be shaped and focused by adjusting the size and morphology of the nanoparticle probe. Refractive index changes on the probed surface will affect the surface plasmon resonance frequency of the particle immobilized at the tip of the probe. This will enable the high-resolution mapping of local dielectric constants of nanoscale heterogeneous materials without the need for dyes or reporter molecules. Such a high resolution, non-invasive imaging method is currently not available. The proposed imaging technique will be useful for characterization of surfaces of materials such as SAMs, lipid bilayers, and soft polymers, and will lead to innovations in nanoscience and technology, surface chemistry, and biotechnology.