MRI: Development of an Atmospheric Pressure Ion Mobility Quadrupole Time-of-flight Mass Spectrometer for Ambient Imaging

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。有了这个来自重大研究仪器（MRI）计划的奖项，Facundo费尔南德斯和同事托马斯奥兰多，马克Sullards和王冬梅从格鲁吉亚理工学院将开发一个大气压离子迁移率质谱仪的环境成像。 所提出的成像质谱仪将结合联合收割机周围离子源与离子迁移率和混合四极杆飞行时间质量分析仪，以实现改进的化学分离。 拟议中的质谱仪将用于许多研究项目中的化学成像，从海藻中的化学防御研究到假冒药品的检测。 该项目将由一组从高中到博士后水平的各种年轻科学家进行。质谱法（MS）是用于识别和表征嵌入复杂基质中的少量化学物质的关键分析方法之一。 成像质谱是一种新的应用，通过它，从材料表面收集物种并进行化学分析。 以这种方式，可以获得物体的化学特定照片。 科学家们可以使用这张照片来确定完整样品中生物或化学过程的细节，而只有最小的扰动。 与费尔南德斯和同事们一起工作的年轻科学家将获得仪器开发方面的第一手经验-这是一个技术驱动的社会的关键技能。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Facundo Fernandez and colleagues Thomas Orlando, Mark Sullards and Dongmei Wang from Georgia Institute of Technology will develop an atmospheric pressure ion mobility mass spectrometer for ambient imaging. The proposed imaging mass spectrometer will combine ambient ion sources with ion-mobility and hybrid quadrupole time-of-flight mass analyzers to achieve improved chemical separation. The proposed mass spectrometer will be used to do chemical imaging in a number of research projects, from the study of chemical defenses in marine algae to the detection of counterfeit pharmaceuticals. The project will be carried out by a diverse group of young scientists, ranging from the high-school to postdoctoral level.Mass Spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex matrices. Imaging mass spectrometry is a new application, whereby, species are collected from a material's surface and chemically analyzed. In this way, a chemically-specific photograph of an object can be obtained. Scientists may use the photograph to determine details of biological or chemical processes in intact samples, with only minimal perturbation. The young scientists working with Fernandez and colleagues will obtain first-hand experience in instrument development -- a critical skill for a technologically-driven society.